Current Issue : January - March Volume : 2013 Issue Number : 1 Articles : 7 Articles
Background: Defects in skin barrier function are associated with an increase risk of eczema and atopic\r\nsensitisation. Ceramide-dominant triple lipid mixture may improve and maintain the infant skin barrier function,\r\nand if shown to be safe and feasible, may therefore offer an effective approach to reduce the incidence of eczema\r\nand subsequent atopic sensitisation. We sort to assess the safety and compliance with daily application of a\r\nceramide-dominant triple lipid formula (EpiCeramââ??¢) commencing in the neonatal period for the prevention of\r\neczema.\r\nMethods: Ten infants (0-4 weeks of age) with a family history of allergic disease were recruited into an open-label,\r\nphase one trial of daily application of EpiCeramââ??¢ for six weeks. The primary outcomes were rate of compliance\r\nand adverse events. Data on development of eczema, and physiological properties of the skin (transepidermal\r\nwater loss, hydration, and surface pH) were also measured.\r\nResults: Eighty percent (8/10) of mothers applied the study cream on 80% or more of days during the six week\r\nintervention period. Though a number of adverse events unrelated to study product were reported, there were no\r\nadverse skin reactions to the study cream.\r\nConclusions: These preliminary results support the safety and parental compliance with daily applications of a\r\nceramide-dominant formula for the prevention of eczema, providing the necessary ground work for a randomised\r\nclinical trial to evaluate EpiCeramââ??¢ for the prevention of eczema.\r\nTrial registration: The study was listed at the Australian/New Zealand Clinical Trial Registry (ANZCTR): reg. no.\r\nACTRN12609000727246....
Background: Acral peeling skin syndrome is a rare autosomal recessive genodermatosis due to a missense\r\nmutation in transglutaminase 5. The skin peeling occurs at the separation of the stratum corneum from the\r\nstratum granulosum.\r\nCase presentation: We present a case of two siblings who developed continuous peeling of the palms and soles\r\nfrom the first year of life. This peeling was more severe on the soles than palms and on younger sibling than elder\r\nsibling. Peeling is worsened by occlusion and sweating.\r\nConclusions: Sporadic cases of Acral Peeling Skin Syndrome occur in African population. There is variability in time\r\nof presentation and clinical severity even within families....
Background. Psoriasis is a common, genetically determined inflammatory and proliferative disease of the skin. Psychological stress\r\ncan exacerbate the disease. This study sought to investigate the depression and anxiety disorders among patients with psoriasis\r\nand control group. Method. In this hospital-based case-control study, One hundred patients with psoriasis (case) referred to the\r\ndermatology department and 100 patients with otolaryngology problems and dermatological healthy volunteers (control) who\r\nreferred to the Otolaryngology Department of Bouali SinaHospital in Sari, Iran, in 2007 were studied. Demographic characteristics\r\nwere recorded. Beck Depression Inventory and Spielberger State-Trait Anxiety Scale I-II were administered to the patients in both\r\ngroups. Data were analyzed using SPSS statistical software and descriptive statistical tests. Results. From One-hundred patients\r\nin each group, 44 (45%) were men. Depression score was 67% and 12% in psoriatic patients and control, respectively. The\r\nBeck depression scores of patients with psoriasis were significantly higher than scores of the control group (P < 0.05). Based\r\non Spielberger State-Trait Anxiety Scale, anxiety was found in 45% of patients in case group and 18% of controls. Conclusion. The\r\nresults revealed that psoriatic patients reported significantly higher degrees of depression and anxiety than controls. In addition,\r\npsoriatic women were more depressed than psoriatic men....
We report the first case of 68-year-old Japanese woman with metastatic HER2-positive extramammary Paget�s disease that showed\r\nthe validity of trastuzumab monotherapy. We administered trastuzumab at a loading dose of 8 mg/kg i.v., followed by a 6 mg/kg\r\nmaintenance dose every three weeks according to a protocol for HER2-positive metastatic breast cancers and a near-complete\r\nresponse was achieved after the tenth infusion. The patient experienced a moderate headache and flushing during the first infusion,\r\nbut had no advanced effects during subsequent infusions with ibuprofen and d-chlorpheniramine maleate. Given the dramatic\r\nresponse, the patient has had 17 infusions of trastuzumab with no disease progression. Thus, trastuzumab has few side effects and\r\nis well tolerated for elderly patients. It may become a new choice of the adjubant therapy of this disease....
Background. Lichen Planus is a chronic mucocutaneous disease of immunological basis and unknown etiology. women with oral\r\nlichen planus may have concomitant manifestations in vulvovaginal areas. Objective. To determine the frequency and risk factors\r\nof genital involvement in a group of Iranian women affected by oral lichen planus. Methods. Thirty-six women with clinical and\r\nhistopathological diagnosis of oral lichen planus were evaluated for demographic, historical, and clinical parameters of the oral\r\ndisease. All the patients were referred for careful vulvovaginal examination, as well as histopathological assessment upon clinical\r\nindication. Results. Nineteen patients complained from genital symptoms but the number of women with the final diagnosis of\r\ngenital lichen planus (n = 2) was too small to show any correlation with the parameters evaluated. Conclusion. In spite of low\r\ngenital involvement possibly due to inadequate patient population, lack of follow-up visits, and contribution of genetic or ethnic\r\nfactors, for conservative patient care, women with the oral lichen planus in particular those having some relevant genital symptoms,\r\nshould preferably be referred for careful vulvovaginal examination.Multicenter cohort studies on women of different geographical\r\nregions or ethnicities who have genital lichen planus alone or in combination with other common sites are encouraged....
Restoration of form and function after burn injury remains challenging, but emerging laser and pulsed light technologies now\r\noffer hope for patients with hypertrophic scars, which may be associated with persistent hyperemia, chronic folliculitis, intense\r\npruritis, and neuropathic pain. In addition to impairing body image, these scars may limit functional recovery, compromise\r\nactivities of daily living, and prevent return to work. Three different platforms are now poised to alter our reconstructive\r\nalgorithm: (1) vascular-specific pulsed dye laser (PDL) to reduce hyperemia, (2) ablative fractional CO2 laser to improve texture\r\nand pliability of the burn scar, and (3) intense pulsed light (IPL) to correct burn scar dyschromia and alleviate chronic folliculitis.\r\nIn this paper, we will provide an overview of our work in this area, which includes a systematic review, a retrospective analysis of\r\nour preliminary experience, and interim data from our on-going, prospective, before-after cohort trial. We will demonstrate that\r\nlaser- and light-based therapies can be combined with each other safely to yield superior results, often at lower cost, by reducing\r\nthe need for reconstructive surgery. Modulating the burn scar, through minimally invasive modalities, may replace conventional\r\nmethods of burn scar excision and yield outcomes not previously possible or conceivable....
Background. Patients with moderate-to-severe psoriasis are often treated with systemic immunosuppressant agents that decrease\r\nimmune system function. For the elderly, these medications are often problematic due to their already immunosuppressed state\r\nand comorbidities. However, there are few studies examining the effects of these medications on the elderly age group. Therefore,\r\nthere is often discomfort among dermatologists treating elderly patients with psoriasis in utilizing systemic agents, frequently\r\nresulting in inadequate treatment. Objective. We review the safety profiles of systemic treatments often used to treat psoriasis\r\nand their possible adverse risks to the geriatric population. Methods. We conducted a search of PubMed�s Medline database of\r\narticles published from 2000 to 2011, which resulted in 14 articles. Conclusion. Treating geriatric patients with moderate-to-severe\r\npsoriasis remains a challenge due to immunosenescence and comorbidities.More studies focusing on psoriasis treatment safety in\r\nthe geriatric population are needed....
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